NGS – Next Generation Sequencing

In our laboratory, Next Generation Sequencing (NGS) is performed for PGT-A and PGT-SR on the principle of massively parallel sequencing, where sequences of thousands to millions of DNA fragments are determined simultaneously.

This modern technique will allow the examination of all embryos of the embryo. The chances of capturing potential genetic changes that could prevent pregnancy, cause abortion or the birth of the affected offspring, significantly increase.

This advanced technology provides more sensitive resolution and more accurate data compared to previously used technologies (FISH, aCGH). The method allows to detect numerical (aneuploidy) and structural changes (rebuilding) at the level of whole chromosomes or their parts (≥10 Mbp) and thus to detect inappropriate embryos in parents with balanced translocation.

Test results are known within 4-5 weeks of biopsy. Once the results are available, you will be informed about them immediately. Cryoembryotransfer embryo is then performed in one of the following cycles and no genetic abnormalities have been detected after examination. Other healthy embryos remain frozen and thus retained for future use.

Long-term statistics show that the transfer of embryos without genetic abnormalities is a crucial breakthrough in the success of IVF cycles. Embryo miscarriages or pregnancy losses are therefore very often caused by genetic defects in the embryo.
 
Thus, using the NGS method for PGT-A and PGT-SR (formerly PGS), it is possible to increase the success of assisted reproduction and reduce the risk of congenital malformations.
 
Would you like to learn more? Make an appointment for a consultation with our fertility experts.
 
Call 00420 549 523 258, e-mail us at ivf@sanatoriumhelios.cz, or use the contact form below. We look forward to helping you.

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